The spillover effect of enforcement actions on bank risk-taking

Enforcement actions (sanctions) aim to penalize guilty companies and provide examples to other com- panies that bad behavior will be penalized. A handful of papers analyze the consequences of sanctions in banking for sanctioned companies, while no papers have investigated the spillover effects on non- sanctioned banks. Focusing on credit-related sanctions, we show the existence of a spillover effect: non- sanctioned banks behave similar to sanctioned banks, depending on their degree of similarity, offloading problematic loans and reducing their lending activit

The puzzling symbiotic X-ray system 4U1700+24

Symbiotic X-ray binaries form a subclass of low-mass X-ray binary systems consisting of a neutron star accreting material from a red giant donor star via stellar wind or Roche lobe overflow. Only a few confirmed members are currently known; 4U 1700+24 is a good candidate as it is a relatively bright X-ray object, possibly associated with the late-type star V934 Her. We analysed the archive {\it XMM}-Newton and Swift/XRT observations of 4U 1700+24 in order to have a uniform high-energy ($0.3-10$ keV) view of the source. We confirmed the existence of a red-shifted O VIII Ly-$\alpha$ transition (already observed in the 2002 {\it XMM}-Newton data) in the high-resolution spectra collected via the RGS instruments. The red-shift of the line is found in all the analysed observations and, on average, it was estimated to be $\simeq 0.009$. We also observed a modulation of the centroid energy of the line on short time scales (a few days) and discuss the observations in the framework of different scenarios. If the modulation is due to the gravitational red-shift of the neutron star, it might arise from a sudden re-organization of the emitting $X$-ray matter on the scale of a few hundreds of km. Alternatively, we are witnessing a uni-polar jet of matter (with typical velocity of $1000-4000$ km s$^{-1}$) possibly emitted by the neutron star in an almost face-on system. The second possibility seems to be required by the apparent lack of any modulation in the observed $X$-ray light curve. We also note also that the low-resolution spectra (both {\it XMM}-Newton and Swift/XRT in the $0.3-10$ keV band) show the existence of a black body radiation emitted by a region (possibly associated with the neutron star polar cap) with typical size from a few tens to hundreds of meters. The size of this spot-like region reduces as the overall luminosity of 4U 1700+24 decreases.Comment: In press on A&

Evidence-based careflow management systems: the case of post-stroke rehabilitation

AbstractThe activities of a care providers’ team need to be coordinated within a process properly designed on the basis of available best practice medical knowledge. It requires a rethinking of the management of care processes within health care organizations. The current workflow technology seems to offer the most convenient solution to build such cooperative systems. However, some of its present weaknesses still require an intense research effort to find solutions allowing its exploitation in real medical practice. This paper presents an approach to design and build evidence-based careflow management systems, which can be viewed as components of a knowledge management infrastructure each health care organization should be provided with to increase its performance in delivering high quality care by efficiently exploiting the available knowledge resources. The post-stroke rehabilitation process has been taken as a challenging care problem to assess our methodology for designing and developing careflow management systems. Then a system was co-developed with a team of rehabilitation professionals who will be committed to use it in their daily work. The system’s main goal is to deliver a full array of rehabilitation services provided by an interdisciplinary team. They are related to identify which patients are most likely to benefit from rehabilitation, manage a rehabilitation treatment plan, and monitor progress both during rehabilitation and after return to a community residence. A model of the rehabilitation process was derived from an international guideline and adapted to the local organization of work. It involves different organizational units, such as wards, rehabilitation units, clinical laboratories, and imaging services. Several organizational agents work within them and play one or more roles. Each role is defined by the goals’ set that she/he must fulfill. Special effort has been given to the design and development of a knowledge-based system for managing exceptions, which may occur in daily medical work as any deviation from the normal flow of activities. It allows either avoiding or recovering automatically from expected exceptions. When they are not expected, organizational agents, with enough power to do that, are allowed to modify the scheduled flow of activities for an individual patient under the only constraint of justifying their decision. After an intensive testing in a research laboratory, the system is now in the process of being transferred in a real working setting with the full support of its future users

Nutrients and pathways that regulate health span and life span

Both life span and health span are influenced by genetic, environmental and lifestyle factors. With the genetic influence on human life span estimated to be about 20\u201325%, epigenetic changes play an important role in modulating individual health status and aging. Thus, a main part of life expectance and healthy aging is determined by dietary habits and nutritional factors. Excessive or restricted food consumption have direct effects on health status. Moreover, some dietary interventions including a reduced intake of dietary calories without malnutrition, or a restriction of specific dietary component may promote health benefits and decrease the incidence of aging-related comorbidities, thus representing intriguing potential approaches to improve healthy aging. However, the relationship between nutrition, health and aging is still not fully understood as well as the mechanisms by which nutrients and nutritional status may affect health span and longevity in model organisms. The broad effect of different nutritional conditions on health span and longevity occurs through multiple mechanisms that involve evolutionary conserved nutrient-sensing pathways in tissues and organs. These pathways interacting each other include the evolutionary conserved key regulators mammalian target of rapamycin, AMP-activated protein kinase, insulin/insulin-like growth factor 1 pathway and sirtuins. In this review we provide a summary of the main molecular mechanisms by which different nutritional conditions, i.e., specific nutrient abundance or restriction, may affect health span and life span

Digital approach for the rehabilitation of the edentulous maxilla with pterygoid and standard implants: The static and dynamic computer-aided protocols

A full-arch rehabilitation of the edentulous upper jaw without grafting procedures exploits the residual alveolar or the basal bone, with the necessity of long implants placed with a particular orientation. The precision in planning and placing the fixtures is fundamental to avoid clinical problems and to allow an acceptable connection with the prosthesis. The computer-aided implantology resulted in more accuracy than the traditional one, with a high standard of correspondence between the virtual project and the real outcome. This paper reports about the two different digital protocols, static and dynamic, as support to implant-borne prosthetic rehabilitation of edentulous maxillae. Two pterygoid and two/four anterior standard implants were seated in both cases by two different operators, without flap raising, and immediately loaded. This approach avoided the posterior cantilever by-passing the maxillary sinus and was adequately planned and realized without any surgical or prosthetic error. The two digital flow-charts were described step by step, underlining each other’s advantages and drawbacks compared to a free-hand approach

NIGER-DELTA: ENVIRONMENT, OGONI CRISIS AND THE STATE

Among the well agreed-on benefits of a guideline computerisation, with respect to the traditional text format, there are the disambiguation, the possibility of looking at the guideline at different levels of detail and the possibility of generating patient-tailored suggestions. Nevertheless, the connection of guidelines with patient records is still a challenging problem, as well as their effective integration into the clinical workflow. In this paper, we describe the evolution of our environment for representing and running guidelines. The main new features concern the choice of a commercial product as the middle layer with the electronic patient record, the consequent possibility of gathering information from different legacy systems, and the extension of this "virtual medical record" to the storage of process data. This last feature allows managing exceptions, i.e. decisions that do not comply with guidelines

Tracking the evolution of riverbed morphology on the basis of uav photogrammetry

Unmanned aerial vehicle (UAV) photogrammetry has recently become a widespread technique to investigate and monitor the evolution of different types of natural processes. Fluvial geomorphology is one of such fields of application where UAV potentially assumes a key role, since it allows for overcoming the intrinsic limits of satellite and airborne-based optical imagery on one side, and in situ traditional investigations on the other. The main purpose of this paper was to obtain extensive products (digital terrain models (DTMs), orthophotos, and 3D models) in a short time, with low costs and at a high resolution, in order to verify the capability of this technique to analyze the active geomorphic processes on a 12 km long stretch of the French–Italian Roia River at both large and small scales. Two surveys, one year apart from each other, were carried out over the study area and a change detection analysis was performed on the basis of the comparison of the obtained DTMs to point out and characterize both the possible morphologic variations related to fluvial dynamics and modifications in vegetation coverage. The results highlight how the understanding of different fluvial processes may be improved by appropriately exploiting UAV-based products, which can thus represent a low-cost and non-invasive tool to crucially support decisionmakers involved in land management practices

Meningococcal B vaccine antigen FHbp variants among disease-causing Neisseria meningitidis B isolates, Italy, 2014–2017

Background Typing of Neisseria meningitidis isolates is crucial for the surveillance of invasive meningococcal disease (IMD). We performed a molecular epidemiology study of N. meningitidis serogroup B (MenB) causing IMD in Italy between 2014 and 2017 to describe circulating strains belonging to this serogroup, with particular regards to the two factor H-binding protein (FHbp) subfamilies present in the bivalent MenB vaccine. Materials and methods A total of 109 culture positive and 46 culture negative MenB samples were collected within the National Surveillance System (NSS) of IMD in Italy and molecularly analyzed by conventional methods. Results Overall, 71 MenB samples showed the FHbp subfamily A and 83 the subfamily B. The subfamily variants were differently distributed by age. The most frequent variants, A05 and B231, were associated with cc213 and cc162, respectively. All MenB with the FHbp A05 variant displayed the PorA P1.22,14 and 85.7% of them the FetA F5-5. The majority of MenB with the FHbp B231 variant showed the PorA P1.22,14 (65.4%) and 84.6%, the FetA F3-6. Conclusion MenB circulating in Italy were characterized by a remarkable association between clonal complex and FHbp variants, although a high degree of genetic diversity observed over time. A dynamic trend in clonal complexes distribution within MenB was detected. Our results stress the importance of continued meningococcal molecular surveillance to evaluate the potential vaccine coverage of the available MenB vaccines